What can I do for severe tooth pain? Home Remedies for Toothache Saltwater Rinse. Until you can get to the dentist, one of the best things you can do is swish warm, salty water around in your mouth. ... OTC Pain Relievers. Dentists suggest acetaminophen for children. ... Cold Compress. If your face is swollen, put an ice pack on your cheek. Will tooth nerve pain go away? Tooth nerve pain is unlikely to go away completely by itself. ... Other treatments for tooth sensitivity include fluoride gel or prescription desensitizing agents, dental fillings, bondings or inlays, depending on what's causing the sensitivity. If your gums have receded, your dentist may suggest a gum graft